Description - Zinc Pyrithione (ZPTO) is a powerful antimicrobial active widely used in hair and skincare formulations for its proven ability to control dandruff, flaking, itching, and fungal/bacterial growth. It works by inhibiting the growth of Malassezia yeast—the primary cause of dandruff—making it a key ingredient in anti-dandruff shampoos, scalp lotions, and cleansing treatments. ZPTO is stable, effective at low concentrations, and compatible with most surfactant systems, making it a popular choice for professional-grade formulations.
Benefits
Controls dandruff, flakiness, and dry scalp.
Reduces itching and scalp irritation.
Provides broad-spectrum antimicrobial protection.
Helps balance unhealthy scalp microbiome.
Effective against fungus, bacteria, and yeast.
Enhances scalp cleanliness and reduces product buildup.
Uses
Anti-dandruff shampoos.
Scalp treatment serums & tonics.
Anti-fungal hair cleansers.
Medicated shampoos for severe dandruff.
Cleansing bars & wash-off products.
Application
Shampoos (SLS/SLES, SCI, AOS, CAPB systems).
Conditioning shampoos.
Scalp lotions (leave-on formulas at lower percentages).
Hair masks with anti-dandruff benefits.
Solubility
Insoluble in water
Dispersible in surfactant bases
Requires proper suspension to avoid settling
pH Value
Most effective in formulations around pH 5.0–7.0
Avoid very acidic formulations, which reduce its stability.
Usage Rate
0.3%–2% depending on product type
Shampoos: 1–2%
Leave-on scalp products: 0.1–0.5%
How It Works
Inhibits growth of dandruff-causing Malassezia yeast.
Disrupts cell membrane function of microbes.
Reduces scalp inflammation triggered by microbial imbalance.
Controls excess oil that supports fungal growth.
Prevents recurrence of dandruff with regular use.
How to Add to Formulation
Add during the cool-down phase below 40–45°C to prevent degradation.
Pre-mix with a non-water medium (glycerin/surfactant) for smooth dispersion.
Use suspending agents (e.g., glycol distearate, xanthan gum) in thin shampoos.
Maintain pH 5–7 for optimal performance.
Ensure uniform mixing to avoid settling in finished product.